New fecal test for non-invasive Helicobacter pylori detection: A diagnostic accuracy study

Table 3 Diagnostic accuracy parameters of the THD fecal test for detecting Helicobacter pylori infection, using ¹³C-urea breath test as the reference standard

Parameter	Complete-case analysis	Best-case analysis	Worst-case analysis
	(n = 290)	(n = 294)1	(n = 294)1
Sensitivity, % (95%CI)	90.2 (84.2 to 96.3)	90.5 (84.6 to 96.4)	87.4 (80.7 to 94.1)
Specificity, % (95%CI)	98.5 (96.8 to 100)	98.5 (96.8 to 100)	98.0 (96.0 to 99.9)
PPV, % (95%CI)	96.5 (92.6 to 100)	96.6 (92.9 to 100)	95.4 (91.0 to 99.8)
NPV, % (95%CI)	95.6 (92.8 to 98.4)	95.6 (92.8 to 98.4)	94.2 (91.0 to 97.4)
Accuracy, % (95%CI)	95.9 (93.6 to 98.2)	95.9 (93.7 to 98.2)	94.6 (92.0 to 97.2)
Positive LR, estimate (95%CI)	59.5 (19.3 to 183.4)	60.0 (19.5 to 185.0)	43.5 (16.4 to 115.0)
Negative LR, estimate (95%CI)	0.10 (0.05 to 0.18)	0.10 (0.05 to 0.18)	0.13 (0.08 to 0.22)

¹The analysis includes four participants with missing data for the THD fecal test. PPV: Positive predictive value; NPV: Negative predictive value; LR: Likelihood ratio; CI: Confidence interval.