Systematic review and meta-analysis on the association of tuberculosis in Crohn’s disease patients treated with tumor necrosis factor-α inhibitors (Anti-TNFα)

Figure 2 Difference of the risk of Mycobacterium tuberculosis infection between patients with Crohn’s disease treated with tumor necrosis factor-alpha inhibitors and those treated with placebo. Risk difference was calculated after arcsine transformation of Mycobacterium tuberculosis incidence (Arcus sinus difference, ASD) and indicated by the numbers on x-axis. Weight: the percentage contribution of an individual study to the overall estimation. The x-axis indicates the risk difference. The vertical dashed line indicates the overall point estimate. The solid horizontal lines show the confidence interval (CI). The size of the black box and diamond is proportional to the corresponding weight.