Systematic review and meta-analysis on the association of tuberculosis in Crohn’s disease patients treated with tumor necrosis factor-α inhibitors (Anti-TNFα)

Table 3 Estimated absolute incidence of Mycobacterium tuberculosis infection in patients with Crohn’s disease treated with tumor necrosis factor-alpha inhibitors and the number of patients with Crohn’s disease who need to be treated with tumor necrosis factor-alpha inhibitors to expect one Mycobacterium tuberculosis case

	Incidence of TB with TNFα treatment (cases/person-years)1	Number of patients treated to see one TB Case in one year
Based on risk difference	177/100000	565
Based on relative odds estimated with background correction	97/100000	1031
Based on relative odds estimated without background correction	117/100000	855

¹The background incidence was assumed to be 20 cases/100000 person-years as reported by Aberra et al[24]. TB: Mycobacterium tuberculosis.