Review
Copyright ©The Author(s) 2018.
World J Gastroenterol. Jul 7, 2018; 24(25): 2661-2672
Published online Jul 7, 2018. doi: 10.3748/wjg.v24.i25.2661
Table 1 Inhibitors of apoptosis for nonalcoholic steatohepatitis
Drug and reagentsTargetsMechanism of actionRef.
Triacsin CIntracellular long-chain acyl-CoA synthetases (ACSL)Triacylglycerol (TAG) accumulation into lipid droplets[112]
EzetimibeAMPK phosphorylationTFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition[113]
BaicalinInhibition of NF-κBNF-κB anti-inflammation signaling pathways[114]
Granulocyte colony stimulating factor (G-CSF)PI3K/AktActivation of PI3K and Akt pathway[115]
Elafibranor (GFT505)PPARα/δAgonist of PPARα/δ receptors[116]
IsoquercitrinDipeptidyl peptidase-IV(DPP-IV)Activation of glucagonlike peptide-1 (GLP-1)[117]
Activated carbon N-acetylcysteine (ACNAC) microcapsulesTelomeraseImproved telomerase activity[118]
3-Acetyl-oleanolic acid (3Ac-OA)Glucose transporter type 2 (GLUT-2), low-density lipoprotein receptor (LDLR)AMPK-related pathways[119]
Meretrix oligopeptides (MMO)NF-κBNF-κB anti-inflammation signaling pathways[120]
Seladelpar (MBX-8025)Proliferator-activated receptor- delta (PPAR-δ)Selective PPAR-δ agonist[121]
ResveratrolSirt1Antioxidant[122]
TBE-31NF-E2 p45-related factor 2 (Nrf2)Regulation of intracellular redox homeostasis[124]