Clinical and prognostic significance of Raf kinase inhibitory protein expression in gastrointestinal stromal tumors

Table 2 Relationship between raf kinase inhibitory protein expression and clinical and pathological characteristics of gastrointestinal stromal tumors

Characteristic	Number	RKIP expression		P value
		Positive (≥ 3)	Negative (< 3)
Gender
Male	33	19	14	0.547
Female	30	15	15
Age (yr)
≥ 56	32	20	12	0.167
< 56	31	14	17
Tumor location
Stomach	35	16	19	0.503
Duodenum	12	8	4
Jejunoileum	14	9	5
Colon	2	1	1
Tumor size (cm)
< 2	11	10	1	< 0.011
2-5	20	15	5
6-10	18	5	13
> 10	14	4	10
NIH risk grade
Very low	10	8	2	< 0.011
Low	19	16	3
Moderate	10	3	7
High	24	7	17
Mitotic figures per 50 HPFs
0	11	8	3	0.218
1-4	35	20	15
5-9	6	2	4
> 10	11	4	7
Mucosal invasion
Yes	33	13	20	0.0151
No	30	21	9

¹RKIP positive percentage were compared using the χ test, P < 0.05 were considered statistically significant. RKIP: Raf kinase inhibitory protein; HPFs: High-power fields.