Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer

Table 1 Patients characteristics and univariate analysis (n = 428)

Characteristics	n (%)	DFS			OS
		t/mo	P value	χ2/Z	t/mo	P value	χ2/Z
Age (median, yr)			0.47	-0.72		0.79	-0.26
< 60	199 (46.5)	40.02			44.97
≥ 60	229 (53.5)	37.72			44.34
Gender			0.42	-0.80		0.56	-0.59
Male	304 (71.0)	37.74			43.99
Female	124 (29.0)	41.38			46.23
Bormann type			0.00	78.58		0.00	70.97
I	33 (7.7)	64.24			64.21
II	189 (44.2)	45.99			51.15
III	200 (46.7)	28.43			35.78
IV	6 (1.4)	17.50			27.33
Tumor size			0.00	-6.17		0.00	-5.87
< 5 cm	243 (56.8)	46.15			50.57
≥ 5 cm	185 (43.2)	29.12			36.84
Location			0.09	4.92		0.22	3.03
Up	90 (21.0)	33.10			40.62
Middle	121 (28.3)	39.98			45.26
Low	217 (50.7)	40.49			45.96
Tumor histological morphology			0.26	2.70		0.36	2.03
Adenocarcinoma	319 (74.5)	39.45			45.15
Absolute signet ring cell carcinoma	3 (0.7)	63.67			63.67
Mixed carcinoma	106 (24.8)	36.09			42.56
Lauren type			0.07	5.28		0.06	5.50
Intestinal	200 (49.5)	41.74			47.59
Diffuse	129 (26.9)	39.28			44.97
Mixed type	99 (23.1)	33.96			40.12
Tumor differentiation			0.01	-2.74		0.01	-2.54
Poor	288 (67.3)	36.54			42.72
Moderate and high	140 (32.7)	43.43			48.58
Vessel invasion			0.00	-6.06		0.00	-5.65
No	299 (69.9)	43.24			48.60
Yes	129 (30.1)	28.49			35.47
Perineural invasion			0.00	-5.63		0.00	-5.26
No	320 (74.8)	42.76			47.95
Yes	108 (25.2)	27.03			34.82
T category			0.00	143.15		0.00	124.25
T1	85 (19.9)	65.15			65.20
T2	24 (5.6)	61.13			62.44
T3	16 (3.7)	59.04			61.33
T4	303 (70.8)	28.61			36.61
N category			0.00	323.31		0.00	322.11
N0	179 (41.8)	62.20			63.47
N1	67 (15.7)	37.22			48.52
N2	84 (19.6)	23.48			33.05
N3	98 (22.9)	10.24			17.52
TNM stage			0.00	285.22		0.00	271.25
I	93 (21.7)	64.16			64.20
II	101 (23.6)	63.27			65.59
III	228 (53.3)	18.44			28.30
IV	6 (1.4)	7.00			9.50
Operation			0.00	-3.45		0.00	-3.79
D1	5 (1.2)	7.00			9.20
D2	423 (98.8)	39.17			45.06
Hepatic metastasis			0.00	-5.31		0.00	-5.10
Yes	46 (10.7)	18.48			28.22
No	382 (89.3)	41.24			46.62
Peritoneum cavity metastasis			0.00	-14.35		0.00	-13.96
Yes	155 (36.2)	14.45			23.47
No	273 (63.8)	52.61			56.66
HIF-1α			0.00	-4.41		0.00	-4.24
Weak-expression	209 (48.8)	44.80			49.58
Over- expression	219 (51.2)	33.06			39.92
P4HB			0.00	-6.88		0.00	-6.91
Weak-expression	213 (49.8)	48.03			52.48
Over- expression	215 (50.2)	29.64			36.87

DFS: Disease-free survival; OS: Overall survival; HIF-1α: Hypoxia-inducible factor-1α; P4HB: Prolyl 4-hydroxylase beta.