Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis

Figure 1 Box-plot of urinary tubular damage biomarkers levels in different groups. A: Urinary NGAL; B: Urinary CysC; C: Urinary L-FABP; D: Urinary IL-18; E: Urinary KIM-1. The boxes in each graph represents the median (middle line), 25^th percentile (bottom line) and 75^th percentile (top line) values, whereas lower and upper whiskers represent data within1.5 IQR of the lower quartile and upper quartile, respectively. Circles represent outliers. Kruskal-Wallis test were used for all comparison and P < 0.05 were considered as have statistical significance, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. ACLF: Acute-on-chronic liver failure; DC: Decompensated cirrhosis; AKI: Acute kidney injury; CHB: Chronic hepatitis B; HC: Healthy controls; NGAL: Neutrophil gelatinase-associated lipocalin; CysC: Cystatin C; L-FABP: Liver-type fatty acid binding protein; IL-18: Interleukin-18; KIM-1: Kidney injury molecule-1.