Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis

Table 3 Univariate and multivariate logistics regression analysis to assess factors associated with the response to terlipressin treatment

Variables	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Age	1.024 (0.975-1.075)	0.344
Gender	0.35 (0.090-1.357)	0.129
Grouping (DC/ACLF)	0.282 (0.087-0.913)	0.035	0.282 (0.087-0.913)	0.035
Baseline serum creatinine	1.074 (0.417-2.77)	0.882
Peak serum creatinine	0.499 (0.268-0.930)	0.029
Cirrhosis	1.50 (0.513-4.385)	0.459
HE	0.318 (0.103-0.981)	0.046	-	0.148
GI bleeding	1.091 (0.262-4.537)	0.905
Ascites	0.735 (0.044-12.330)	0.831
SBP	0.452 (0.125-1.633)	0.226
Pulmonary infection	0.970 (0.324-2.904)	0.956
ALT	0.997 (0.993-1.001)	0.153
AST	0.997 (0.993-1.002)	0.095
Serum albumin	0.986 (0.895-1.1087)	0.782
Serumbilirubin	0.956 (0.917-0.996)	0.032
Serum sodium	1.071 (0.986-1.163)	0.103
INR	0.462 (0.260-0.823)	0.009
Leukocyte count	0.903 (0.816-0.999)	0.048	-	0.180
MAP	0.998 (0.937-1.062)	0.944
Child-Pugh score	0.809 (0.608-1.076)	0.146
MELD	0.921 (0.870-0.975)	0.004
Treatment time	1.020 (0.978-1.065)	0.352

DC: Decompensated chirrhosis; ACLF: Acute-on-chronic liver failure; HE: Hepatic encephalopathy; GI: Gastrointestinal; SBP: Spontaneous bacterial peritonitis; ALT: Alanine amino transaminases; AST: Aspartate transaminases; INR: International normalized ratio; MAP: Mean arterial pressure; MELD: Model of end-stage liver disease score.