Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis

Figure 5 Hepatic global gene expression analysis in DIO-nonalcoholic steatohepatitis mice. A and B: Principal component analysis; C: Venn diagram of differentially expressed genes, compared to vehicle treatment; D: Overview of KEGG pathway-enriched gene groups; E: Relative expression of prototypic NASH genes; F: Relative expression of selected genes. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs vehicle controls. OCA: Obeticholic acid; NASH: Nonalcoholic steatohepatitis.