Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection

Table 2 Association of IRF5 rs13242262A/T and rs10488630A/G with hepatitis B virus-related liver cirrhosis n (%)

IRF5 variants	HC, n = 242	CHB, n = 99	LC, n = 131	HCC, n = 149	LC vs CHB
					OR (95%CI)	P value
rs13242262 A/T
AA	67 (27.7)	27 (27.3)	32 (24.4)	45 (30.2)	Reference
AT	119 (49.2)	59 (59.6)	65 (49.6)	77 (51.7)	1.0 (0.5-2.0)	NS
TT	56 (23.1)	13 (13.1)	34 (26.0)	27 (18.1)	3.1 (1.2-7.8)	0.014
Allele
A	253 (52.3)	113 (57)	129 (49.2)	165 (55.3)	Reference
T	231 (47.7)	85 (43)	133 (50.8)	133 (44.7)	1.5 (1.1-2.3)	0.040
Dominant
AA	67 (27.7)	27 (27.3)	32(24.4)	45 (30.2)	Reference
AT + TT	175 (72.3)	72 (72.7)	99 (75.6)	104 (69.8)	1.3 (0.7-2.6)	NS
Recessive
AA + AT	186 (76.9)	86 (87)	97 (74.0)	122 (81.9)	Reference
TT	56 (23.1)	13 (13)	34 (26.0)	27 (18.1)	2.8 (1.3-5.9)	0.0057
rs10488630 A/G
AA	115 (47.5)	58 (58.6)	59 (45.1)	73 (49.0)	Reference
AG	104 (43.0)	36 (36.4)	56 (42.7)	63 (42.3)	1.6 (0.9-2.9)	0.100
GG	23 (9.5)	5 (5.0)	16 (12.2)	13 (8.7)	3.0 (1.0-9.5)	0.045
Allele
A	334 (69)	152 (76.8)	174 (66.4)	209 (72.3)	Reference
G	150 (31)	46 (23.2)	88 (33.6)	89 (27.7)	1.7 (1.1-2.6)	0.019
Dominant
AA	115 (47.5)	58 (58.6)	59 (45.0)	73 (49)	Reference
AG + GG	127 (52.5)	41 (41.4)	72 (55.0)	76 (51)	1.8 (1.0-3.2)	0.035
Recessive
AA + AG	219 (90.5)	94 (94.9)	115 (87.8)	136 (91.3)	Reference
GG	23 (9.5)	5 (5.1)	16 (12.2)	13 (7.8)	2.4 (0.8-7.2)	0.100

HC: Healthy controls; CHB: Chronic hepatitis B; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma.