Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease

Table 5 Significant associations between serum biomarkers and anthropometric parameters [z-scores based on bone age (n = 49)] - unadjusted analyses

Variable	Mid-arm circumference BA-z-scores	Subscapular skinfoldBA-z-scores	Triceps skinfoldBA-z-scores	WeightBA-z-scores	BMIBA-z-scores
WBC	-0.191 (-0.36, -0.02)2 0.0293	-0.12 (-0.24, -0.01) 0.04		-0.16 (-0.28, -0.04) 0.008
ESR				-0.03 (-0.04, -0.01) 0.003	-0.02 (-0.03, -0.001) 0.037
CRP			-0.03 (-0.07, -0.0001) 0.049	-0.06 (-0.10, -0.02) 0.008
Albumin				0.73 (0.28, 1.18) 0.002
IGF-1 BA-z-scores				0.2 (0.01, 0.38) 0.039

¹Regression Coefficient for Unadjusted Analyses [i.e., one serum biomarker (independent variable) per model and no adjustment for potential confounding];

²(95% confidence interval);

³P-value. BA z-score: z score based on bone age; BMI: Body mass index; WBC: White blood cell; ESR: Erythrocyte sedimentation rate; IGF-1: Insulin-like growth factor-1; CRP: C-reactive protein.