Gastrointestinal stromal tumors: A multidisciplinary challenge

Table 1 Tyrosine kinase inhibitor election based on genes mutations

Gene	Mutation	TKI. Dose
KIT	Exon 11	Imatinib-Mesylate 400 mg/d
	Exon 13
	Exon 17
	Exon 9	Imatinib-Mesylate 800 mg/d
PDGFRA	Exon 18. D842V mutation	Sunitinib 50 mg/d
		Regorafenib 160 mg/d
	Exon 12	Imatinib-Mesylate 400 mg/d
	Exon 14
	Exon 18. Non D842V mutations.
Wild-type		Sunitinib 50 mg/d
		Regorafenib 160 mg/d