Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression

Figure 2 Pooled incidence and distribution of preexisting putative and pretreatment reverse transcriptase mutations compiled using data from 50 previous studies. The distribution and overall incidence of RT region is presented; numbers indicate the pooled incidence rate of the RT mutation in a total of 8435 treatment-naïve patients. ^aPre-existing RT mutation associated with the progression of HCC in treatment-naïve patients; ^bA-B interdomain region.