Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression

Figure 1 Pooled incidence and distribution of preexisting primary and secondary reverse transcriptase mutations compiled using data from 50 previous studies. The distribution and overall incidence of RT region is presented; numbers indicate the pooled incidence rate of the RT mutation in a total of 8,435 treatment-naïve patients. ^aPre-existing RT mutation associated with the progression of HCC in treatment-naïve patients.