Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression

Table 5 Relationship of preexisting reverse transcriptase mutations with disease severity

Type of mutation in RT	Chang in HBsAg	Genotype	Location	Disease progression	P value	Ref.
rtL80I2	NC	C	South Korea	HCC	0.036	[33]
rtD134N4	sI126S/N	B, C	China	HCC	0.007	[114]
rtN139K/T/H4	sT131N/P	C	South Korea	HCC	0.008	[33]
rtY141F5	sM307T	Ce	Taiwan	HCC	0.029	[37]
rtM204I/V1	sW196L/S/W	C	South Korea	HCC	0.021	[33]
rtF221Y3	NA	B,C,D	China	HCC, poor survival rate	0.028/0.004	[20,115]
rtI224V4	NC	C	China	HCC	0.005	[116]
rtM309K5	NA	C	China	HCC	0.007	[116]

HBV polymerase RT mutation;

¹Primary;

²Secondary;

³Putative;

⁴Pretreatment;

⁵Novel RT mutation. HCC: Hepatocellular carcinoma; NA: Not available; NC: Not changed; RT: Reverse transcriptase.