Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients

Table 3 Correlation between CA199 level and clinicopathological characteristics in gallbladder carcinoma patients n (%)

Characteristics	CA199 level		P value
	≤ 25.45 U/mL (n = 57)	> 25.45 U/mL (n = 97)
Age (yr)
≤ 60	24 (15.6)	32 (20.8)	0.299
> 60	33 (21.4)	65 (42.2)
Sex
Male	23 (14.9)	40 (26.0)	0.914
Female	34 (21.1)	57 (37.0)
Cholecystolithiasis
Absent	32 (20.8)	47 (30.5)	0.406
Present	25 (16.2)	50 (32.5)
Diabetes
Absent	45 (29.2)	71 (46.1)	0.447
Present	12 (7.8)	26 (16.9)
Jaundice
Absent	53 (34.4)	76 (49.4)	0.022
Present	4 (2.6)	21 (13.6)
Blood groups
A	19 (12.3)	24 (15.6)	0.303
B	21 (13.6)	35 (22.7)
AB	1 (0.6)	8 (5.2)
O	16 (10.4)	30 (19.5)
Pathological types
Adenosquamous carcinoma	0 (0)	3 (1.9)	0.299
Adenocarcinoma	57 (37.0)	93 (60.4)
Papillocarcinoma	0 (0)	1 (0.6)
Degree of differentiation
Poor	33 (21.4)	61 (39.6)	0.069
Moderate-well	24 (15.6)	36 (23.4)
Resection margin status
Negative	45 (29.2)	51 (33.1)	0.001
Positive	12 (7.8)	46 (29.9)
Maximum tumor diameter (cm)
≤ 2.45	30 (19.5)	38 (24.7)	0.131
> 2.45	27 (17.5)	59 (38.3)
T stage
Tis-T1a	7 (4.5)	3 (1.9)	< 0.001
T1b-T2b	18 (11.7)	11 (7.1)
T3	32 (20.8)	71 (46.1)
T4	0 (0.0)	12 (7.8)
N stage
N0	43 (27.9)	55 (35.7)	0.056
N1	11 (7.1)	36 (23.4)
N2	3 (1.9)	6 (3.9)
Distant metastasis
Absent	53 (34.4)	89 (57.8)	0.783
Present	4 (2.6)	8 (5.2)
TNM stage
0-I stage	11 (7.1)	5 (3.2)	< 0.001
IIA-IIB stage	12 (7.8)	4 (2.6)
IIIA-IIIB stage	27 (17.5)	65 (42.2)
IVA-IVB stage	7 (4.5)	23 (14.9)
Fibrinogen concentration (g/L)
≤ 3.47	37 (24.0)	38 (24.7)	0.003
> 3.47	20 (13.0)	59 (38.3)