Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease

Table 4 Diagnostic performance of autotaxin and conventional fibrosis indicators for predicting severe fibrosis (≥ F3) in patients with non-alcoholic fatty liver disease

	AUC	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
All patients
ATX	0.75	51	91	63	86	82
HA	0.82	93	63	44	96	70
4C7S	0.87	75	88	64	92	85
APRI	0.82	60	89	62	88	82
FIB-4	0.85	79	74	48	92	75
Male
ATX	0.74	62	82	40	92	79
HA	0.76	85	72	41	95	75
4C7S	0.81	69	89	56	94	86
APRI	0.74	77	64	29	93	66
FIB-4	0.81	92	75	41	98	78
Female
ATX	0.78	73	86	67	89	82
HA	0.86	78	86	68	91	83
4C7S	0.89	78	90	75	92	87
APRI	0.86	63	95	83	87	86
FIB-4	0.85	80	75	56	90	76

AUC: Area under the receiver operating characteristic curve; PPV: Positive predictive value; NPV: Negative predictive value; ATX: Autotaxin; HA: Hyaluronic acid; 4C7S: Type 4 collagen•7S; APRI: AST to platelet ratio; FIB-4: Fibrosis-4 index.