Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease

Table 1 Clinicopathological features of 186 patients with non-alcoholic fatty liver disease

	All (n = 186)	Male (n = 80)	Female (n = 106)
	Median (IQR)/n	Median (IQR)/n	Median (IQR)/n	P value1
Age (yr)	56 (46-65)	50 (38-59)	61 (54-66)	< 0.001
BMI (kg/m2)	26.2 (23.8-29.6)	26.1 (24.3-29.4)	26.5 (23.6-29.7)	NS
Laboratory data
Albumin (g/dL)	4.5 (4.3-4.7)	4.6 (4.4-4.8)	4.4 (4.2-4.7)	< 0.001
T-bil (mg/dL)	0.87 (0.69-1.17)	0.94 (0.74-1.26)	0.81 (0.67-1.07)	< 0.05
AST (IU/L)	41 (30-65)	39 (30-62)	42 (30-69)	NS
ALT (IU/L)	63 (38-97)	68 (43-103)	53 (33-89)	NS
γ-GT (IU/L)	54 (35-92)	64 (43-99)	50 (32-81)	< 0.05
TG (mg/dL)	122 (92-159)	122 (91-159)	121 (95-159)	NS
LDL-C (mg/dL)	130 (107-151)	132 (105-154)	130 (109-149)	NS
HDL-C (mg/dL)	51 (44-60)	48 (44-56)	55 (47-63)
Plt (× 104/μL)	23.1 (18.5-26.8)	23.0 (19.6-26.7)	23.3 (17.6-26.9)	NS
HbA1c (%)	5.9 (5.7-6.6)	5.9 (5.6-6.5)	5.9 (5.7-6.6)	NS
FBG (mg/dL)	108 (98-121)	108 (98-121)	108 (97-121)	NS
IRI (mU/L)	11.2 (7.2-16.7)	10.5 (6.8-16.3)	11.5 (7.4-17.2)	NS
HOMA-IR	3.0 (1.9-4.6)	2.9 (1.8-4.5)	3.2 (2.0-4.7)	NS
Fe (μg/dL)	111 (90-137)	120 (92-146)	104 (88-129)	< 0.05
Ferritin (ng/mL)	146 (79-274)	172 (126-293)	113 (58-236)	< 0.001
AFP (ng/mL)	3.2 (2.2-4.8)	2.8 (2.1-4.0)	3.4 (2.6-5.2)	< 0.01
Fibrosis markers
HA (ng/mL)	51 (28-91)	41 (25-62)	63 (34-118)	< 0.001
4C7S (ng/mL)	4.6 (3.8-5.7)	4.5 (3.8-5.5)	4.7 (3.8-6.6)	NS
FIB-4	1.35 (0.94-2.18)	1.12 (0.77-1.88)	1.53 (1.13-2.51)	< 0.001
APRI	0.69 (0.46-1.13)	0.66 (0.44-1.03)	0.71 (0.46-1.25)	NS
Histological findings
Steatosis (1/2/3)	57/90/39	24/41/15	33/49/24	NS
Lobular inflammation (0/1/2/3)	9/101/69/7	6/48/23/3	3/53/46/4	< 0.05
Ballooning (0/1/2)	43/98/45	22/44/14	21/54/31	NS
Fibrosis (0/1/2/3/4)	35/89/19/34/9	16/43/8/13/0	19/46/11/21/9	NS

¹Comparison between male and female subjects. IQR: Interquartile range; BMI: Body mass index; T-bil: Total bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γ-GT: Gamma-glutamyltransferase; TG: Triglyceride; LDL-C: Low density lipoprotein cholesterol; HDL-C: High density lipoprotein cholesterol; Plt: Platelet; FBG: Fasting blood glucose; IRI: Immunoreactive insulin; HOMA-IR: Homeostasis model assessment of insulin resistance; AFP: Alpha-fetoprotein; HA: Hyaluronic acid; 4C7S: Type 4 collagen•7S; FIB-4: Fibrosis-4 index; APRI: AST to platelet ratio; NS: Not significant.