Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma

doi:10.3748/wjg.v24.i10.1120

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2018; 24(10): 1120-1133
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1120

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Figure 7 Proteinase-activated receptor 2 mediates the activation of ERK and further induces epithelial-mesenchymal transition. A: The protein levels of ERK and p-ERK in HepG2 and SMMC-7721 cells; B: The morphological changes in HepG2 and SMMC-7721 cells after proteinase-activated receptor 2 knockdown; C and D: The protein levels of EGR-1, Snail, E-cadherin, and N-cadherin in HepG2 and SMMC-7721 cells. GAPDH was selected as an endogenous control.

Citation: Sun L, Li PB, Yao YF, Xiu AY, Peng Z, Bai YH, Gao YJ. Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. World J Gastroenterol 2018; 24(10): 1120-1133
URL: https://www.wjgnet.com/1007-9327/full/v24/i10/1120.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i10.1120