Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma

Figure 6 Proteinase-activated receptor 2 knockdown inhibits tumor metastasis in nude mice. A: HepG2 and SMMC-7721 cells were injected into the spleen of nude mice to form liver metastases. The appearance of mice after 4 wk is shown; B: Tumors grown on the liver; C: Tumor number on each liver was counted; D: Percentage of mice with liver metastases (n = 10 per group). ^bP < 0.01.