Differential analysis of lymph node metastasis in histological mixed-type early gastric carcinoma in the mucosa and submucosa

Table 4 Clinicopathologic features of submucosa-invasive early gastric carcinoma according to histological type n (%)

Variable	MT, n = 24	Pure U, n = 20	Pure D, n = 89	P value	P (Bonferroni corrected)
Age (yr)				0.008	MT vs PU, 0.423
≤ 60	14 (58.3)	14 (70.0)	32 (36.0)		MT vs PD, 0.048
> 60	10 (41.7)	6 (30.0)	57 (64.0)		PU vs PD, 0.005
Gender				< 0.001	MT vs PU, 0.069
Male	15 (62.5)	7 (35.0)	70 (78.7)		MT vs PD, 0.104
Female	9 (37.5)	13 (65.0)	19 (21.3)		PU vs PD, < 0.001
Size (cm)	2.6 ± 1.3	2.8 ± 1.4	2.3 ± 1.1	0.166
Location				0.019	MT vs PU, 0.128
U	5 (20.8)	1 (5.0)	31 (34.8)		MT vs PD, 0.191
M/L	19 (79.2)	19 (95.0)	58 (65.2)		PU vs PD, 0.008
Gross type				0.028	MT vs PU, 0.199
Elevated	6 (25.0)	2 (10.0)	35 (39.3)		MT vs PD, 0.195
Flat/depressed	18 (75.0)	18 (90.0)	54 (60.7)		PU vs PD, 0.012
Ulcer				0.369
Absent	5 (20.8)	7 (35.0)	32 (36.0)
Present	19 (79.2)	13 (65.0)	57 (64.0)
H. pylori infection				0.997
Absent	7 (29.2)	6 (30.0)	26 (29.2)
Present	17 (70.8)	14 (70.0)	63 (70.8)
LV invasion				0.325
Absent	15 (62.5)	15 (75.0)	69 (77.5)
Present	9 (37.5)	5 (25.0)	20 (22.5)
LNM				0.008	MT vs PU, 0.375
Absent	15 (62.5)	12 (60.0 )	76 (85.4)		MT vs PD, 0.012
Present	9 (37.5)	8 (40.0)	13 (14.6)		PU vs PD, 0.009

MT: Mixed-type; PU: Pure undifferentiated; PD: Pure differentiated; U: Upper; M/L: Middle/lower; LV: Lymphovascular; LNM: Lymph node metastasis.