Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?

Table 4 Difference of bi-phase normalized iodine concentration between different clinical-pathological subgroups

Varieties	n	nIC-AP		nIC-VP
		mean ± SD	P value	mean ± SD	P value
Depth of invasion
< T4	7	0.101 ± 0.042	0.195	0.363 ± 0.079	0.302
> T4	27	0.120 ± 0.031		0.392 ± 0.063
Nodal status
N0	11	0.112 ± 0.033	0.321	0.385 ± 0.085	0.923
N1-3	23	0.125 ± 0.035		0.387 ± 0.057
Histologic differentiation
Highly and moderately differentiated	17	0.100 ± 0.028	0.003a	0.352 ± 0.048	0.001a
Poorly differentiated	17	0.132 ± 0.031		0.421 ± 0.065
Lauren subtype
Intestinal type	15	0.099 ± 0.029	0.016a	0.347 ± 0.048	0.006a
Mixed type	7	0.120 ± 0.032		0.417 ± 0.061	0.0131a
Diffuse type	12	0.135 ± 0.030	0.0052a	0.417 ± 0.067	0.002a
Tumor location
Cardia/Fundus	14	0.109 ± 0.033	0.445	0.385 ± 0.046	0.874
Gastricum	9	0.128 ± 0.024		0.387 ± 0.064
Antrum	11	0.116 ± 0.040		0.387 ± 0.091
Sex
Male	23	0.113 ± 0.033	0.377	0.390 ± 0.069	0.633
Female	11	0.124 ± 0.035		0.378 ± 0.062

¹One-way ANOVA-LSD, mixed type vs intestinal type;

²Diffuse type vs intestinal type.

^aP < 0.05. nIC-AP: Normalized iodine concentration in arterial phase; nIC-VP: Normalized iodine concentration in venous phase; MVD: Microvessel density; SD: Standard deviation.