Fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy: A retrospective study at a single center

Table 4 Symptom relief, manometry outcomes, and reflux complications of the 21 patients who experienced mucosal penetration during peroral endoscopic myotomy

Follow-up period (mo), median (range)	42.0 (9-62)
Symptom relief
Eckardt score, median (range)
Pre-treatment	5.0 (4-10)
Post-treatment	1.0 (0-4)
Pre/post-treatment difference value	4.8 (1-9)
Treatment success (Eckardt score ≤ 3), n (%)	20 (95.2)
Manometry outcomes
Manometry follow-up rate, n (%)	15 (71.4)
LESP (mmHg), median (range)
Pre-treatment	31.9 (21.9-67.1)
Post-treatment	20.3 (6.0-41.0)
Pre/post-treatment difference value	14.1 (9.6-35.2)
Post-POEM esophagitis on EGD
LA-A	1
LA-B	2
Overall, n (%)	3 (14.3)
Gas-related complications, n
Pneumothorax	1
Pneumoperitoneum	1
Pneumomediastinum	1
Overall	3

POEM: Peroral endoscopic myotomy; EGD: Esophagogastroduodenoscopy; LA-A: Los Angeles classification A; LA-B: Los Angeles classification B; LESP: Lower esophageal sphincter pressure.