Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis

Figure 3 Da-Cheng-Qi decoction alleviates pancreas and liver damages in rats with severe acute pancreatitis. Rats (n = 6 per group) were orally administered with different doses of Da-Cheng-Qi decoction (DCQD) (6 g/kg for the LDG, 12 g/kg for the MDG, and 24 g/kg for the HDG) 2 h after operation. At 24 h after operation, pancreas and liver samples were collected for pathological analysis and stained with hematoxylin and eosin (HE); A: Pathological pictures of the pancreas (the left) and liver tissues (the right, HE, × 200); B: Pathological scores for the pancreas and liver damages. The results are represented as the mean ± SD. ^aP < 0.05 vs SOG and ^bP < 0.05 vs MG. SOG: Sham operation group; MG: Model group; LDG: Low-dose group; MDG: Medium-dose group; HDG: High-dose group.