Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis

Table 6 Predictors of mortality of the 102 patients with cryptogenic cirrhosis

Outcome	Univariate analysis, HR (95%CI)	P value	Multivariate analysis, HR (95%CI)	P value
Overall mortality
Age at diagnosis	1.07 (1.03-1.10)	< 0.001	1.11 (1.04-1.18)	0.001
Male sex	1.10 (0.55-2.20)	NS	1.07 (0.46-2.48)	NS
Child B vs A	9.75 (2.85-33.32)	< 0.001	8.35 (2.16-32.29)	< 0.002
Child C vs A	23.62 (6.64-84.05)	< 0.005	34.64 (7.5-160.7)	< 0.001
Renal impairment1	2.63 (1.31-5.30)	< 0.007	0.65 (0.28-1.54)	NS
Hyponatremia2	2.66 (1.34-27)	< 0.005	0.84 (0.36-1.95)	NS

¹Renal impairment: serum creatinine > 1.20 mg/dL;

²Hyponatremia: serum Na < 135 mE/L. In addition to the variables reported in the table, analysis included also: ALT/AST, α-fetoprotein, metabolic syndrome, obesity, serum cholesterol, type 2 diabetes mellitus, cardiovascular events. NS: Not significant.