Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?

Table 5 Statistical correlations between N stage variation and clinico-pathological variables

Variable	N stage variation			P value
	None	Downstaging	Upstaging
Sex
M	19	35	7
F	37	26	6	0.0347
Age
≤ 67 yr	27	34	5
> 67 yr	29	27	7	0.565
Site
Upper	16	33	7
Medium	10	11	3
Lower	25	16	1
Extensive	5	1	2	0.0183
Circumferential spread
One-third	25	28	8
Middle	17	17	1
Complete	14	16	4	0.582
Craniocaudal extension
< 3 cm	10	14	5
≥ 3 cm	46	47	8	0.27
Distance from the anal verge
≥ 1 cm	1	4	1
< 1 cm	55	57	12	0.402
Histotype
NOS	49	59	13
Mucinous	7	2	0	0.0851
cT
2	4	8	0
3	38	42	12
4	14	11	1	0.265
Histological grade
1	3	2	0
2	39	50	11
3	14	9	2	0.512
Dworak grade
0	14	6	3
1	25	23	8
2	16	13	2
3	0	11	0
4	1	8	0	0.0013
Death due to disease
No	30	50	9
Yes	26	11	4	0.0043
Recurrence
No	25	47	9
Yes	31	14	4	0.0013