Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?

Table 4 Statistical correlations between T stage variation and clinico-pathological variables

Variable	T stage variation			P value
	None	Downstaging	Upstaging
Sex
M	58	83	0
F	28	39	7	0.001
Age
≤ 67 yr	40	64	2
> 67 yr	46	58	5	0.375
Site
Upper	33	56	4
Medium	12	19	1
Lower	35	41	1
Extensive	6	6	1	0.692
Circumferential spread
One-third	41	51	2
Middle	22	37	3
Complete	23	34	2	0.792
Craniocaudal extension
< 3 cm	21	29	1
≥ 3 cm	65	93	6	0.832
Distance from the anal verge
≥ 1 cm	5	6	0
< 1 cm	81	116	7	0.789
Histotype
NOS	77	118	5
Mucinous	9	4	2	0.01
cN
cN0	29	66	3
cN+	57	56	4	0.0145
Histological grade
1	0	4	2
2	68	107	4
3	18	11	1	< 0.0001
Dworak grade
0	23	7	0
1	38	35	7
2	23	27	0
3	2	19	0
4	0	34	0	< 0.0001
Death due to disease
No	52	100	5
Yes	34	22	2	0.0027
Recurrence
No	45	93	4
Yes	41	29	3	0.0014