Retrospective Cohort Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Feb 28, 2017; 23(8): 1387-1396
Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1387
Table 4 Univariate and multivariate analyses of cancer specific survival and disease free survival
Univariate analysis CSS1
Multivariate analysis CSS12
Univariate analysis DFS3
Multivariate analysis DFS23
5-yr CSSP valueHazard ratioP value5-yr DFSP valueHazard ratioP value
Age (yr)63%0.0091.7 (0.8-3.6)0.15571%0.2261.2 (0.5-2.9)0.668
≥ 8078%79%
< 80
Gender0.2740.9 (0.5-1.6)0.7620.6821.1 (0.5-2.2)0.865
Male68%77%
Female73%74%
Ethnicity0.293--0.608--
Ashkenazi73%73%
Sephardic65%78%
Arab88%69%
Other79%93%
Second malignancies0.497--0.429--
Yes75%81%
No70%74%
Family hx of cancer0.068--0.096--
Yes78%82%
No68%71%
Family hx of CRC0.0240.3 (0.1-0.8)0.0150.0480. 2 (0.1-0.8)0.016
Yes86%91%
No70%73%
Performance status0.00031.2 (0.5-3)0.620.0682.1 (0.7-6.3)0.175
0-177%78%
2-453%60%
Mode of Diagnosis0.0241 (0.3-3.4)0.9730.235--
Symptoms68%74%
Screening90%85%
Tumor location0.102--0.723--
Right colon66%77%
Left colon/rectum75%75%
Histology< 0.00015.7 (1.5-21.1)0.009< 0.00016.9 (1.7-28)0.007
NOS/mucinous/other74%77%
Signet ring cell33%48%
Grade0.05--0.561--
187%71%
2-369%76%
T----
T192%< 0.0001100%< 0.0001
T290%82%
T373%72%
T439%76%
N0.0003--0.001--
N089%81%
N179%72%
N256%57%
M< 0.0001------
M085%
M126%
TNM stage< 0.0001-0.014
I94%10.43390%1-
II90%1.9 (0.4-8.7)0.01377%3.5 (0.8-15.6)0.107
III73%6.7 (1.5-30.1)< 0.000163%8.4 (1.9-36.4)0.004
IV26%20 (4.6-87.6)---
LVI0.073--0.848--
Yes57%79%
No75%75%
VVI0.272--0.791--
Yes65%72%
No75%76%
Obstruction0.0012.3 (0.99-5.4)0.0520.0012.95 (1.1-7.9)0.03
Yes49%49%
No74%79%
Perforation0.00013.5 (1.1-10.9)0.0280.262--
Yes28%64%
No73%76%
Adjuvant/neoadjuvant tx----
Yes87%0.13772%0.236
No78%80%
Local Tx to metastatic sites------
Yes41%0.007
No20%