Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model

doi:10.3748/wjg.v23.i8.1353

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2017; 23(8): 1353-1366
Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1353

Table 6 Effect of oral administration of Cd-EtOHE or Cd-HexP for 21 d on the expression of cyclooxygenase-2, proliferating cell nuclear antigen and superoxide dismutase in trinitrobenzenesulfonic acid-induced ulcerative colitis in rats

Group	Dose (mg/kg)	COX-2 (μm²)	PCNA (μm²)	SOD (μm²)
Non-colitics	-	230 (110-700)	1425 (60-7890)	400 (80-1.115)
Colitics	-	505 (100-1.450)^d	5380 (850-15.960)^f	165 (10-1.000)^f
Cd-EtOHE	125	90 (10-2.590)^c	1630 (90-14.790)^c	400 (50-1.480)^c
Cd-HexP	62.5	205 (20-790)^c	1570 (250-9.500)^c	435 (20-1.650)^c

Results are expressed as median (minimum-maximum) of the analyzed parameters (n = 7-9). For nonparametric data, median (minimum-maximum) was used, with Kruskal-Wallis and Dunn’s test a posteriori.

^cP < 0.001 vs colitic group;

^dP < 0.05 and

^fP < 0.001 vs non-colitic group. COX-2: Cyclooxygenase-2; PCNA: Proliferating cell nuclear antigen; SOD: Superoxide dismutase; Cd: Combretum duarteanum; EtOHE: Ethanolic extract; HexP: Hexane phase.

Citation: de Morais Lima GR, Machado FDF, Périco LL, de Faria FM, Luiz-Ferreira A, Souza Brito ARM, Pellizzon CH, Hiruma-Lima CA, Tavares JF, Barbosa Filho JM, Batista LM. Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model. World J Gastroenterol 2017; 23(8): 1353-1366
URL: https://www.wjgnet.com/1007-9327/full/v23/i8/1353.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i8.1353