Cerebral magnetic resonance imaging in quiescent Crohn’s disease patients with fatigue

Table 4 Mental status

	CD patients (n = 20)	Controls (n = 17)	P value
Global cognitive functioning
MMSE (total score), mean ± SD	28.9 (1.62)	29.65 (0.49)	0.87
Memory
Verbal
WMS memory quotient, mean ± SD3	109.2 (10.5)	115.7 (8.7)	0.72
Non verbal
WMS visual reproduction (total score), mean ± SD3	11.6 (2.7)	12.9 (2.2)	0.75
WAIS-R Digit Span forward, mean ± SD	5.4 (1.0)	6.5 (1.3)	0.15
WAIS-R Digit Span backward, mean ± SD	4.5 (1.0)	5.2 (0.9)	0.15
Executive functioning
WFT, mean ± SD1
No. of good answers	42.7 (7.8)	48.2 (9.8)	0.29
No. of perseverative errors	0.28 (0.5)	0.47 (0.8)	0.58
Stroop Color-Word test, mean ± SD
Stroop 1 time (s)	43.9 (7.2)	39.2 (8.6)	0.41
Stroop 1 No. of errors	0.2 (0.4)	0.1 (0.3)	0.98
Stroop 2 time (s)	56.6 (8.3)	53.8 (6.9)	0.62
Stroop 2 No. of errors	0.3 (0.8)	0 (0.0)	0.21
Stroop 3 time (s)	88.3 (14.7)	76.6 (8.8)	0.22
Stroop 3 No. of errors	0.6 (1.5)	0.13 (0.3)	0.20
Stroop interference index	50.1 (7.8)	56.1 (5.5)	0.06
TMT, mean ± SD
Part A time (s)	30.3 (11.8)	22.1 (8.5)	0.08
Part A no. of errors	0.1 (0.2)	0.1 (0.2)	0.56
Part B time (s)	61.8 (29.2)	50.1 (17.4)	0.72
Part B no. of errors	0.1 (0.2)	0.2 (0.5)	0.41
WAIS-R Digit Symbol, mean ± SD2
Total score	59.7 (8.4)	71.0 (6.2)	0.06
No. of errors	0 (0.0)	0.1 (0.3)	0.63
Digit cancellation test, mean ± SD4
Total score	436.2 (88.1)	498.6 (82.9)	0.16
No. of good answers (%)	57.3 (29.5)	78.9 (20.9)	0.16
HADS, mean ± SD	13.1 (7.3)	4.8 (2.9)	< 0.001
Anxiety	7.5 (3.8)	3.7 (2.7)	0.002
Depression	6.1 (4.0)	0.9 (1.1)	< 0.001
SF-36
Physical functioning	72.9 ± 20.2	96.6 ± 3.4	< 0.001
Social functioning	52.0 ± 29.0	90.7 ± 9.8	< 0.001
Role physical problem	71.3 ± 37.4	2.9 ± 8.3	< 0.001
Role emotional problem	40.4 ± 46.1	2.0 ± 8.1	0.002
Bodily pain	35.3 ± 20.7	5.6 ± 12.6	< 0.001
General health perception	65.8 ± 18.8	82.0 ± 15.2	< 0.001
Mental health	63.6 ± 16.0	80.4 ± 10.9	0.001
Vitality	30.1 ± 18.3	72.9 ± 14.3	< 0.001

¹Missing in 2 CD patients;

²Missing 1 CD patient and 1 healthy control;

³Missing in 2 healthy controls;

⁴Missing in 5 patients and 3 healthy controls. To correct for multiple testing, the level of significance was set at P < 0.006 for the SF-36 score. MMSE: Mini Mental State Examination; WMS: Wechsler Memory Scale; WAIS-R: Wechsler Adult Intelligence Scale-Revised; WFT: Word Fluency Test; TMT: Trial Making test; HADS: Hospital Anxiety Depression Scale; CD: Crohn’s disease.