Analysis of 12 variants in the development of gastric and colorectal cancers

Table 3 Genotypic and allelic distributions of the investigated polymorphisms for patients with gastric cancer in comparison to control group

Genotype	GC	Control	P value1	OR (95%CI)1	Genotype	GC	Control	P value1	OR (95%CI)1
CASP8	120	475			RP2/RP2	18 (15.1)	154 (32.5)	0.189	0.673 (0.372-1.216)
DEL/DEL	11 (9.2)	90 (19.0)	0.650	0.892 (0.545-1.461)	Allele RP1	0.54	0.41
INS/DEL	70 (58.3)	230 (48.4)			Allele RP2	0.46	0.59
INS/INS	39 (32.5)	155 (32.6)	0.080	1.936 (0.924-4.058)	NFKB1	120	473
Allele DEL	0.38	0.43			DEL/DEL	34 (28.3)	117 (24.7)	0.0062	2.918 (1.352-6.298)
Allele INS	0.62	0.57			INS/DEL	71 (59.2)	246 (52.0)
MDM2	120	475			INS/INS	15 (12.5)	110 (23.3)	0.88	0.959 (0.5662-1.610)
DEL/DEL	13 (10.8)	33 (6.9)	0.199	1.365 (0.849-2.192)	Allele DEL	0.58	0.51
INS/DEL	46 (38.3)	168 (35.4)			Allele INS	0.42	0.49
INS/INS	61 (50.9)	274 (57.7)	0.0212	0.409 (0.192-0.872)	PAR1	113	473
Allele DEL	0.30	0.25			DEL/DEL	66 (58.4)	273 (57.7)	0.068	0.482 (0.221-1.054)
Allele INS	0.70	0.75			INS/DEL	36 (31.9)	169 (35.7)
TP53	120	475			INS/INS	11 (9.7)	31 (6.6)	0.949	0.984 (0.601-1.610)
DEL/DEL	91 (75.8)	350 (73.7)	0.999	138214253.0 (0.000)	Allele DEL	0.74	0.76
INS/DEL	27 (22.5)	116 (24.4)			Allele INS	0.26	0.24
INS/INS	2 (1.7)	9 (1.9)	0.247	0.708 (0.395-1.270)	CYP2E1	116	475
Allele DEL	0.87	0.86			DEL/DEL	94 (81.0)	398 (83.8)	0.999	276187721.0 (0.000)
Allele INS	0.13	0.14			INS/DEL	21 (18.1)	73 (15.4)
TYMS	120	475			INS/INS	1 (0.9)	4 (0.8)	0.574	1.193 (0.644-2.212)
DEL/DEL	16 (13.3)	65 (13.7)	0.409	1.231 (0.752-2.015)	Allele DEL	0.90	0.91
INS/DEL	53 (44.2)	224 (47.2)			Allele INS	0.10	0.09
INS/INS	51 (42.5)	186 (39.2)	0.867	1.060 (0.536-2.096)	CYP19A1	120	475
Allele DEL	0.35	0.37			DEL/DEL	18 (15.0)	76 (16.0)	0.654	1.127 (0.669-1.897)
Allele INS	0.65	0.63			INS/DEL	67 (55.8)	248 (52.2)
XRCC1	119	474			INS/INS	35 (29.2)	151 (31.8)	0.415	1.334 (0.667-2.671)
DEL/DEL	10 (8.4)	35 (7.4)	0.346	1.257 (0.781-2.021)	Allele DEL	0.43	0.42
INS/DEL	48 (40.3)	179 (37.8)			Allele INS	0.57	0.58
INS/INS	61 (51.3)	260 (54.8)	0.396	0.697 (0.303-1.604)	UGT1A1	120	464
Allele DEL	0.29	0.26			*1/*1	49 (40.8)	206 (44.5)	0.792	1.109 (0.515-2.386)
Allele INS	0.71	0.74			*1/*28	57 (47.5)	209 (45.0)
IL1A	120	475			*28/*28	12 (10.0)	46 (9.9)	0.445	1.205 (0.746-1.946)
DEL/DEL	17 (14.2)	86 (18.1)	0.626	0.882 (0.522-1.460)	*36/*1	2 (1.7)	3 (0.6)
INS/DEL	63 (52.5)	246 (51.8)			*36/*37	0 (0.0)	0 (0.0)	0.585	1.941 (0.180-20.973)
INS/INS	40 (33.3)	143 (30.1)	0.143	1.705 (0.835-3.482)	*1/*37	0 (0.0)	0 (0.0)
Allele DEL	0.40	0.44			Allele *36	0.01	0.01
Allele INS	0.60	0.56			Allele *1	0.65	0.67
IL4	119	474			Allele *28	0.34	0.32
RP1/RP1	28 (23.6)	69 (14.5)	0.0022	2.857 (1.490-5.479)	Allele *37	0.00	0.00
RP1/RP2	73 (61.3)	251 (53.0)

Data for GC and Control columns are presented as n or n (%).

¹Analysis of combined genotypes (INS/INS vs others, or DEL/DEL vs others) with adjusted values for confounding factors (sex and European ancestry) in logistic regression;

²Statistically significant. GC: Gastric cancer.