Pharmacokinetics and pharmacodynamics of Shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injury

Table 1 Pharmacokinetic parameters of the seven components of Shengjiang decoction

Component	Group	Tmax (h)	T1/2 (h)	MRT (0-t) (h)	CL (L/h/kg)	Cmax (μg/L)	AUC (0-t)( μg/L/h)
Emodin	CG + SJD	0.56 ± 0.27	0.85 ± 1.09	4.13 ± 0.41	396 ± 147	16.23 ± 4.11	44.78 ± 18.87
	MG + SJD	0.50 ± 0.28	0.26 ± 0.12	3.08 ± 0.48a	619 ± 193a	16.47 ± 7.35	34.34 ± 14.78
ALEM	CG + SJD	3.89 ± 2.12	4.15 ± 2.08	4.77 ± 0.40	261 ± 97	17.88 ± 5.90	80.61 ± 23.75
	MG + SJD	0.83 ± 0.62a	0.46 ± 0.49a	3.18 ± 0.45a	564 ± 209a	13.77 ± 3.00	38.51 ± 16.63a
Rhein	CG + SJD	0.44 ± 0.18	0.71 ± 0.65	2.32 ± 0.40	3.07 ± 0.39	4388 ± 957	6136.71 ± 816.0
	MG + SJD	0.39 ± 0.14	0.82 ± 0.57	2.19 ± 0.21	2.41 ± 0.35a	5206 ± 1703	8025.27 ± 1074.26a
CHRY	CG + SJD	0.50 ± 0.19	1.02 ± 1.63	2.93 ± 0.57	411 ± 118	22.46 ± 7.78	39.12 ± 5.9
	MG + SJD	0.56 ± 0.27	0.96 ± 0.66	4.04 ± 0.63a	271 ± 76a	17.44 ± 3.71	58.90 ± 23.74
Curcumin	CG + SJD	0.44 ± 0.18	0.71 ± 0.27	4.60 ± 1.26	15957 ± 8161	0.93 ± 1.42	1.01 ± 0.86
	MG + SJD	0.52 ± 0.08	0.69 ± 0.43	5.38 ± 0.71	25172 ± 11861	0.18 ± 0.04	0.56 ± 0.23
DEME	CG + SJD	0.89 ± 0.27	0.60 ± 0.49	4.90 ± 0.58	1518 ± 944	2.08 ± 0.37	10.62 ± 3.41
	MG + SJD	0.50 ± 0.19	0.36 ± 0.45	5.83 ± 0.91	1064 ± 717	1.99 ± 0.91	8.60 ± 1.90
BISD	CG + SJD	0.50 ± 0.28	3.18 ± 0.30	4.44 ± 0.46	4117 ± 677	1.03 ± 0.27	3.97 ± 0.52
	MG + SJD	0.61 ± 0.55	2.99 ± 0.14	3.93 ± 1.34	5159 ± 1829	0.83 ± 0.09	3.28 ± 0.47

^aP < 0.05 vs CG + SJD. ALEM: Aloe-emodin; CHRY: Chrysophanol; DEME: Demethoxycurcumin; BISD: Bisdemethoxycurcumin; Cmax: Maximum concentration; Tmax: Time of maximum concentration; MRT: Mean residence time.