Recurrence in node-negative advanced gastric cancer: Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series

Table 1 Clinical, pathological, and surgical features of 478 N0 gastric cancer patients n (%)

	Values
Male	291 (60.9)
Female	187 (39.1)
mean age (range)	67.1 (31-90)
Tumor markers1 (positive)	33/282
Tumor location
Upper	67 (14.1)
Middle	104 (21.7)
Lower	261 (55.6)
Multiple	46 (9.6)
Tumor mean size (range), cm	4.311 (0.8-14)
Tumor invasion (T)
T2	278 (58.2)
T3	181 (37.8)
T4a	19 (4.0)
Lauren histotype
Intestinal	315 (65.9)
Diffuse	81 (16.9)
Mixed / Unavailable	82 (17.1)
Histological grading (G)
G1	87 (18.2)
G2	287 (60.0)
G3	104 (21.8)
Type of surgery
Subtotal gastrectomy	266 (55.7)
Total gastrectomy	212 (44.3)
Mean retrieved node number2	26.2
(range)	(15-85)
Associated resections	53 (11.1)
(splenectomies)	[41 (8.5)]
30-d mortality	9 (1.88)
Major morbidity	61 (12.7)

¹CEA and/or CA19.9 above the normal values of 7 ng/mL and 36 UI/mL, respectively;

²This value reflects the exclusion from our analysis of patients with less than 15 retrieved nodes.