Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival

Table 2 Univariate and multivariate analysis of overall survival

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age	0.989	0.970-1.009	0.271	-	-	-
Sex	0.489	0.293-0.815	0.006	0.346	0.154-0.776	0.010
Smoke status	0.745	0.595-0.932	0.010	1.071	0.761-1.507	0.694
Alcohol intake	0.817	0.546-1.223	0.327	-	-	-
G grade	1.131	0.836-1.530	0.533	-	-	-
TNM stage	2.001	1.564-2.560	< 0.001	1.755	1.288-2.390	< 0.001
CHI3L1	1.002	1.001-1.004	0.011	1.004	1.002-1.005	< 0.001
SCCA	1.065	1.028-1.104	< 0.001	1.056	1.013-1.100	0.010
CEA	1.048	0.972-1.130	0.224	-	-	-
Treatment	1.402	1.218-1.613	< 0.001	1.167	0.979-1.391	0.084

Variables: Age, ≥ 60 vs < 60; gender, female vs male; smoke, smoker vs non-smoker; alcohol intake, yes vs no; grade, grade 3 vs grade 2 vs grade 1; stage, IV vs III vs II vs treatment, surgery vs chemotherapy vs chemoradiotherapy; -: Represent “date not available”. CHI3L1: Chitinase 3-like 1; SCCA: Squamous cell carcinoma antigen; CEA: Carcinoembryonic antigen.