Tenofovir vs lamivudine plus adefovir in chronic hepatitis B: TENOSIMP-B study

doi:10.3748/wjg.v23.i41.7459

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Gastroenterol. Nov 7, 2017; 23(41): 7459-7469
Published online Nov 7, 2017. doi: 10.3748/wjg.v23.i41.7459

Table 4 Average costs per patient (€, 2014)

Costs - average, € (SD)	TDF	LAM+ADV	Difference TDF vs LAM+ADV	P value
Costs - average, € (SD)	(n = 22)	(n = 24)	Difference TDF vs LAM+ADV	P value
Studied medication	2966 (69)	4218 (558)	-1252	< 0.001¹
Concomitant medication	218 (599)	82 (213)	136	0.484
Medical visits	505 (158)	500 (137)	5	0.942
Tests	1388 (182)	1363 (242)	25	0.834
Admissions and surgeries	0 (0)	0 (0)	0 (0)	NA
Total	4943 (1059)	5811 (1538)	-868	< 0.001¹

¹Statistically significant difference. ADV: Adefovir dipivoxil; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; LAM: Lamivudine; TDF: Tenofovir dipivoxil fumarate.

Citation: Rodríguez M, Pascasio JM, Fraga E, Fuentes J, Prieto M, Sánchez-Antolín G, Calleja JL, Molina E, García-Buey ML, Blanco MÁ, Salmerón J, Bonet ML, Pons JA, González JM, Casado MÁ, Jorquera F, the TENOSIMP-B Research Group. Tenofovir vs lamivudine plus adefovir in chronic hepatitis B: TENOSIMP-B study. World J Gastroenterol 2017; 23(41): 7459-7469
URL: https://www.wjgnet.com/1007-9327/full/v23/i41/7459.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i41.7459