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©The Author(s) 2017.
World J Gastroenterol. Nov 7, 2017; 23(41): 7387-7396
Published online Nov 7, 2017. doi: 10.3748/wjg.v23.i41.7387
Published online Nov 7, 2017. doi: 10.3748/wjg.v23.i41.7387
Table 2 Cox regression analysis: Fecal calprotectin as predictor of disease flare
| Disease flare | ||||
| Univariate | Multivariate | |||
| HR (95%CI) | P | HR (95%CI) | P | |
| FC (HR per 100 μg/g) | 1.212 (1.147-1.280) | < 0.001 | 1.745 (1.275-2.388) | 0.001 |
| Age (in yr) | 1.018 (0.998-1.037) | 0.055 | 0.973 (0.937-1.011) | NS |
| Gender (male vs female) | 0.577 (0.322-1.033) | 0.064 | 0.643 (0.151-2.749) | NS |
| Disease duration (in mo) | 1.000 (0.998-1.002) | > 0.2 | ||
| Disease (UC vs CD) | 1.373(0.664-2.838) | > 0.2 | ||
| Extraintestinal manifestations (none vs present) | 1.085 (0.856-1.375) | > 0.2 | ||
| Treatment at baseline | 0.915 (0.650-1.287) | > 0.2 | ||
| 5-ASA | 0.408 (0.125-1.331) | 0.137 | 8.805 (0.753-102.913) | NS |
| Immunomodulators (AZA, 6-MP) | 1.193 (0.575-2.474) | > 0.2 | ||
| Anti-TNF | 0.754 (0.391-1.455) | > 0.2 | ||
| Previous Surgery for disease | 1.494 (0.591-3.776) | > 0.2 | ||
| CRP (HR per 1mg/dL) | 1.062 (1.034-1.091) | < 0.001 | 1.010 (0.935-1.093) | NS |
| WBC (HR per 1000) | 1.144 (1.028-1.273) | 0.014 | 1.197 (1.001-1.432) | 0.049 |
| Hgb (HR per 1 g/dL) | 0.887 (0.702-1.121) | > 0.2 | ||
| PLT (HR per 1000) | 1.003 (0.998-1.008) | > 0.2 | ||
- Citation: Kostas A, Siakavellas SI, Kosmidis C, Takou A, Nikou J, Maropoulos G, Vlachogiannakos J, Papatheodoridis GV, Papaconstantinou I, Bamias G. Fecal calprotectin measurement is a marker of short-term clinical outcome and presence of mucosal healing in patients with inflammatory bowel disease. World J Gastroenterol 2017; 23(41): 7387-7396
- URL: https://www.wjgnet.com/1007-9327/full/v23/i41/7387.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i41.7387