Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine

doi:10.3748/wjg.v23.i41.7369

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 23, Issue 41

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (9327)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-3) series.

Item

Count

PDF

607

WORD

219

HTML

6051

Figures (1-3)

255

Tables (1-3)

173

Sum=7305

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1000

Download

1022

Sum=2022

Nov 7, 2017 (publication date) through Apr 25, 2024

Times Cited of This Article

Times Cited (16)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Nov 7, 2017; 23(41): 7369-7386
Published online Nov 7, 2017. doi: 10.3748/wjg.v23.i41.7369

Table 2 Seven upregulated proteins with no DE mRNA targeted by 15 downregulated miRNAs

Protein					microRNA
Uniprot	Symbol	Title	Linear FC	Adj. P value	miRBase ID	logFC	LinFC	AveExpr	P Value	Adj. P value

O43852	CALU	Calumenin	1.86	0.0162	hsa-let-7a	-1.44	-2.72	12.58	1.30E-04	0.00396
					hsa-let-7b	-2.61	-6.11	12.84	1.71E-06	0.00017
					hsa-let-7c	-3.45	-10.94	11.26	2.39E-06	0.00021
					hsa-let-7d	-2.66	-6.34	12.12	2.20E-06	0.00020
					hsa-let-7e	-1.40	-2.65	12.39	6.41E-05	0.00236
					hsa-let-7f	-2.85	-7.20	8.75	5.04E-06	0.00034
					hsa-let-7g	-1.06	-2.08	8.90	2.99E-04	0.00737
					hsa-let-7i	-2.31	-4.95	10.22	2.35E-06	0.00021
					hsa-miR-29a	-1.63	-3.09	9.69	1.14E-04	0.00361
					hsa-miR-200a	-2.68	-6.43	9.16	4.14E-04	0.00965
					hsa-miR-200b	-2.54	-5.81	10.40	2.63E-05	0.00129
P20810	CAST	Calpastatin	2.39	0.00011	hsa-miR-125a-3p	-3.14	-8.83	5.84	3.26E-05	0.00150
					hsa-miR-224	-2.44	-5.42	7.35	8.21E-04	0.01667
					hsa-miR-375	-4.06	-16.67	8.29	1.50E-05	0.00083
P21333	FLNA	Filamin-A	3.59	0.00048	hsa-miR-125a-3p	-3.14	-8.83	5.84	3.26E-05	0.00150
P13797	PLS3	Plastin-3	5.88	0.00006	hsa-miR-200b	-2.54	-5.81	10.40	2.63E-05	0.00129
P78330	PSPH	Phosphoserine phosphatase	2.22	0.0004	hsa-miR-200b	-2.54	-5.81	10.40	2.63E-05	0.00129
P35241	RDX	Radixin	5.57	0.00012	hsa-let-7a	-1.44	-2.72	12.58	1.30E-04	0.00396
					hsa-let-7b	-2.61	-6.11	12.84	1.71E-06	0.00017
					hsa-let-7c	-3.45	-10.94	11.26	2.39E-06	0.00021
					hsa-let-7d	-2.66	-6.34	12.12	2.20E-06	0.00020
					hsa-let-7e	-1.40	-2.65	12.39	6.41E-05	0.00236
					hsa-let-7f	-2.85	-7.20	8.75	5.04E-06	0.00034
					hsa-let-7g	-1.06	-2.08	8.90	2.99E-04	0.00737
					hsa-let-7i	-2.31	-4.95	10.22	2.35E-06	0.00021
					hsa-miR-31	-1.94	-3.83	12.79	7.91E-05	0.00274
Q13885	TUBB2A	Tubulin beta-2A chain	1.46	0.00388	hsa-miR-29a	-1.63	-3.09	9.69	1.14E-04	0.00361

Seven proteins found upregulated in the Caco-2 cell line relative to the HT-29 cell line and predicted to be targeted by 15 unique anti-correlated/downregulated microRNAs.

Citation: O’Sullivan F, Keenan J, Aherne S, O’Neill F, Clarke C, Henry M, Meleady P, Breen L, Barron N, Clynes M, Horgan K, Doolan P, Murphy R. Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine. World J Gastroenterol 2017; 23(41): 7369-7386
URL: https://www.wjgnet.com/1007-9327/full/v23/i41/7369.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i41.7369