Glucagon-like peptide-2 modulates the nitrergic neurotransmission in strips from the mouse gastric fundus

Figure 1 Influence of glucagon-like peptide-2 on the neurally-induced contractile responses. A: Typical tracing showing the electrical field stimulation (EFS)-induced contractile responses at different stimulation frequencies (left panel). Ten min after the addition of 2 nmol/L glucagon-like peptide-2 (GLP-2) to the bath medium (right panel), the amplitude of the EFS-induced excitatory responses is decreased in the whole range of stimulation frequencies employed; B: Bar chart of the effects of GLP-2 (2 and 20 nmol/L) on the mean amplitude of the EFS-induced contractile responses elicited at different stimulation frequencies. Excitatory responses are expressed as percentage of the muscular contraction evoked by 2 μmol/L methacholine, taken as 100%. All values are mean ± SE of six preparations. ^aP < 0.05 vs the ctr ^bP < 0.05 and P > 0.05 vs the ctr and vs 2 nmol/L GLP-2, respectively, ANOVA and Newman-Keuls post-test).