Mitofusin-2 mediated mitochondrial Ca2+ uptake 1/2 induced liver injury in rat remote ischemic perconditioning liver transplantation and alpha mouse liver-12 hypoxia cell line models

Figure 3 Remote ischemic perconditioning models model causes low expression of Mfn2 and alters MICUs expression. Expression of Mfn2 and MICUs was measured by WB (A) and qRT-PCR (B). Both sham and RIC groups showed lower expression of Mfn2 and altered MICUs expression, but no significant change was observed in expression of mitochondrial Ca²⁺ uniporter. Mfn2: Mitofusin-2; MICUs: Mitochondrial Ca²⁺ uptake 1/2; OLT: Orthotopic liver transplantation; qRT-PCR: Quantitative real-time-PCR; RIC: Remote ischemic perconditioning; WB: Western blotting. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.