Retrospective Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Oct 14, 2017; 23(38): 7025-7036
Published online Oct 14, 2017. doi: 10.3748/wjg.v23.i38.7025
Table 5 Postoperative pathology n (%)
VariableTotal,n = 1000First 10 yr,1993-2002Second 10 yr,2003-2012Last 5 yr,2013-2017
Site of the tumor
Ampullary tumor312 (31.2)92 (30.7)145 (32.8)75 (29)
Pancreatic head mass556 (55.6)171 (57)257 (58.1)128 (49.6)0.0001
CBD duct tumor41 (4.1)16 (5.3)13 (2.9)12 (4.7)
Duodenal tumor61 (6.1)20 (6.7)27 (6.1)14 (5.4)
Uncinate process mass30 (3)1 (0.3)029 (11.3)
Pathological diagnosis
Adenocarcinoma836 (83.6)250 (83.3)357 (80.7)229 (88.8)
Undifferentiated carcinoma20 (2)1 (1.7)19 (4.3)0
Papillary cystadenocarcinoma6 (0.6)4 (1.3)2 (0.5)00.0001
Lymphoma4 (0.4)2 (0.6)2 (0.5)0
Neuroendocrine tumor28 (2.8)12 (4)10 (2.3)6 (2.3)
Solid pseudopapillary tumor20 (2)5 (1.7)8 (1.8)7 (2.7)
Chronic pancreatitis24 (2.4)6 (2)14 (3.2)4 (1.6)
Benign cyst12 (1.2)3 (1)8 (1.8)1 (0.4)
Adenoma with dysplasia41 (4.1)15 (5)19 (4.3)7 (2.7)
Gastrointestinal stromal tumor2 (0.2)01 (0.2)1 (0.4)
Glomus1 (0.1)1 (0.3)00
Adenosquamous2 (0.2)1 (0.3)1 (0.2)0
Pleomorphic adenoma1 (0.1)01(0.2)0
Adenomyoma3 (0.3)003 (1.2)
Malignant870 (87)258 (86)382 (86.4)230 (89.1)0.38
Borderline48 (4.8)17(5.7)18 (4.1)13 (5.1)
benign82 (8.2)25 (8.3)42 (9.5)15 (5.8)
Number of dissected lymph node6 (0-40)5 (0-18)6 (0-40)6 (0-40)0.59
Number of lymph node infiltration0 (0-14)0 (0-3)0 (0-14)0 (0-14)0.07
Perineural infiltration187 (18.7)62 (20.7)75 (17)50 (19.9)0.09
Perivascular infiltration134 (134)40 (13.3)66 (14.9)28 (10.9)0.13
Pancreatic safety margin
R191 (9.1)40 (13.3)41 (9.3)10 (3.8)0.01
R215 (1.5)7 (2.3)6 (1.4)2 (0.7)

  • Citation: El Nakeeb A, Askar W, Atef E, Hanafy EE, Sultan AM, Salah T, shehta A, Sorogy ME, Hamdy E, Hemly ME, El-Geidi AA, Kandil T, Shobari ME, Allah TA, Fouad A, Zeid MA, Eneen AAE, El-Hak NG, Ebidy GE, Fathy O, Sultan A, Wahab MA. Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases. World J Gastroenterol 2017; 23(38): 7025-7036
  • URL: https://www.wjgnet.com/1007-9327/full/v23/i38/7025.htm
  • DOI: https://dx.doi.org/10.3748/wjg.v23.i38.7025