Genetic biomarkers for hepatocellular cancer risk in a caucasian population

Table 4 Odds ratios and corresponding 95%CI for hepatocellular carcinoma compared to hepatitis B/hepatitis C infected patients according to the viral status

Gene	SNP	Allelic change	Mod	HCC vs HBV/HCV
				HBV-positive		HCV-positive
				OR (95%CI)1	P value	OR (95%CI)1	P value
ERCC1	rs3212986	G>T	Dom	0.59 (0.30-1.15)	0.1231	0.33 (0.18-0.60)	0.0003b
XRCC3	rs1799794	A>G	Rec	2.23 (0.39-12.82)	0.3695	6.73 (0.82-55.03)	0.0753
GST-P1	rs1138272	C>T	Dom	0.40 (0.14-1.15)	0.0881	0.41 (0.16-1.02)	0.0558
CYP17A1	rs743572	T>C	Dom	0.45 (0.22-0.93)	0.0315a	0.51 (0.27-0.97)	0.0384a
ABCB1	rs1128503	C>T	Rec	4.18 (1.55-11.29)	0.0048b	1.49 (0.71-3.11)	0.2893

¹Estimated through logistic regression model, adjusted for sex, age and HBV and/or HCV infection.

^aP < 0.05,

^bP < 0.01. HCC: Hepatocellular carcinoma; SNP: Single-nucleotide polymorphism; HBV: Hepatitis B viral; HCV: Hepatitis C viral.