Genetic biomarkers for hepatocellular cancer risk in a caucasian population

doi:10.3748/wjg.v23.i36.6674

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 28, 2017; 23(36): 6674-6684
Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6674

Table 2 Distribution of gene polymorphisms in patients with hepatocellular carcinoma, in hepatitis B/hepatitis C -positive patients, and in healthy controls n (%)

Gene	SNP	Genotype	HCC group	HBV/HCV group	Healthy group
ERCC1	rs3212986	GG	126 (67.7)	82 (49.1)	91 (47.4)
		GT	44 (23.7)	78 (46.7)	81 (42.2)
		TT	16 (8.6)	7 (4.2)	20 (10.4)
XRCC3	rs1799794	AA	128 (66.7)	108 (65.1)	137 (71.7)
		AG	52 (27.1)	55 (33.1)	49 (25.7)
		GG	12 (6.3)	3 (1.8)	5 (2.6)
GST-P1	rs1138272	CC	172 (92.5)	139 (83.2)	182 (94.8)
		CT	13 (7.0)	27 (16.2)	10 (5.2)
		TT	1 (0.5)	1 (0.6)	0 (0.0)
CYP17A1	rs743572	TT	72 (38.1)	39 (23.4)	54 (28.4)
		TC	84 (44.4)	88 (52.7)	91 (47.9)
		CC	33 (17.5)	40 (24.0)	45 (23.7)
ABCB1	rs1128503	CC	54 (28.1)	52 (31.1)	58 (30.2)
		CT	92 (47.9)	93 (55.7)	95 (49.5)
		TT	46 (24.0)	22 (13.2)	39 (20.3)

HCC: Hepatocellular carcinoma; SNP: Single-nucleotide polymorphism; HBV: Hepatitis B viral; HCV: Hepatitis C viral.

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Citation: De Mattia E, Cecchin E, Polesel J, Bignucolo A, Roncato R, Lupo F, Crovatto M, Buonadonna A, Tiribelli C, Toffoli G. Genetic biomarkers for hepatocellular cancer risk in a caucasian population. World J Gastroenterol 2017; 23(36): 6674-6684
URL: https://www.wjgnet.com/1007-9327/full/v23/i36/6674.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i36.6674

De Mattia E, Cecchin E, Polesel J, Bignucolo A, Roncato R, Lupo F, Crovatto M, Buonadonna A, Tiribelli C, Toffoli G. Genetic biomarkers for hepatocellular cancer risk in a caucasian population. World J Gastroenterol 2017; 23(36): 6674-6684 [PMID: 29085212 DOI: 10.3748/wjg.v23.i36.6674]

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