Access to biologicals in Crohn’s disease in ten European countries

Table 4 Number of Crohn’s disease patients and the use of biologicals

Country	Estimated number of CD patients/source		Number of patients on biologicals1/source		Patients on biologicals per 100000 population (calculated)	Patients on biologicals per 1000 patients (calculated)
Cz	8768	Rencz et al[3], 2015 (based on estimation)	990	Rencz et al[3], 2015	9.4	112.9
Fr	72522	Kirchgesner et al[28], 2017 (administrative database)	22671	Estimation based on Kirchgesner et al[28], 2017	34.0	312.6
D	180000	Estimate by the collaborating expert based on CD incidence and prevalence in two regional cohort studies from the 90ties.	27000	Estimation (based on the estimated % of patients on biologicals and the total number of CD patients)	32.9	150.0
Hu	9775	Rencz et al[3], 2015 (based on epidemiology study)	1870	Rencz et al[3], 2015	19.0	191.3
Lv	1695	Rencz et al[3], 2015 (based on estimation)	3	Rencz et al[3], 2015	0.2	1.8
Pl	32049	Rencz et al[3], 2015 (based on estimation)	888	Rencz et al[3], 2015	2.3	27.7
Ro	11000	Estimate for 2016 by the collaborating expert based on National database including 13 IBD centers	253	Rencz et al[3], 2015	1.3	23.0
Sk	3687	Rencz et al[3], 2015 (epidemiology study)	690	Rencz et al[3], 2015	12.7	187.1
Es	60000	Arin Letamendia et al[29], 2008 (prospective, population-based study)	15000	Estimation (based on the estimated % of patients on biologicals from the ENEIDA database2 and the total number of CD patients)	32.3	250.0
Se	34318	SWIBREG3 combined with the Swedish National Patient Register	5270	SWIBREG3 combined with The Prescribed Drug Register	53.5	153.6

¹The sources of the number of patients on biologicals in Rencz et al[3], 2015 are National gastroenterology societies, ministries of health, IMS data, personal communication;

²ENEIDA is a large Spanish database (ENEIDA), promoted by the Spanish Working Group in Crohn’s and Colitis (GETECCU) (partial, not population based study);

³Swedish national quality registry for IBD. Cz: The Czech Republic; Fr: France; D: Germany; Hu: Hungary; Lv: Latvia; Pl: Poland; Ro: Romania; Sk: Slovakia; Es: Spain; Se: Sweden; GDP: Gross domestic product; CD: Crohn’s disease.