Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer

Table 3 Total mortality and association with highest tertile level of inflammatory factors

Factor	Total mortality		Total mortality adjusted1
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.0 (1.0-1.1)	0.006	1.1 (1.0-1.1)	< 0.001
TNM stage II	1.5 (0.5-4.0)	0.464	1.2 (0.4-3.2)	0.777
TNM stage III	1.8 (0.7-4.8)	0.228	2.2 (0.8-6.1)	0.141
TNM stage IV	6.8 (2.6-17.9)	< 0.001	14.6 (6.0-42.6)	< 0.001
Radical surgery	0.2 (0.1-0.4)	< 0.001	0.3 (0.1-0.6)	0.002
Preoperative treatment	0.8 (0.4-1.5)	0.454	0.7 (0.4-1.4)	0.338
Adjuvant treatment	1.1 (0.6-1.7)	0.842	0.7 (0.4-1.3)	0.226
CCL1	3.2 (1.7-5.9)	< 0.001	2.7 (1.4-5.4)	0.004
CCL3	2.0 (1.1-3.6)	0.030	1.2 (0.6-2.2)	0.605
CCL15	2.3 (1.2-4.3)	0.010	1.9 (1.0-3.7)	0.046
CCL20	3.1 (1.6-6.0)	0.001	2.2 (1.1-4.3)	0.021
CCL26	1.7 (1.0-3.0)	0.055	1.7 (0.9-3.0)	0.078
CX3CL1	3.3 (1.8-6.1)	< 0.001	2.3 (1.2-4.5)	0.014
CXCL1	1.9 (1.0-3.4)	0.038	1.4 (0.8-2.6)	0.295
CXCL10	2.1 (1.1-4.0)	0.017	1.3 (0.7-2.6)	0.387
CXCL13	1.8 (1.1-3.2)	0.033	2.0 (1.0-3.7)	0.039
CXCL16	1.6 (0.9-2.8)	0.139	1.7 (0.9-3.1)	0.113
IFN-γ	3.1 (1.6-6.1)	0.001	3.5 (1.6-7.5)	0.001
IL-1β	2.1 (1.2-3.8)	0.012	1.7 (0.9-3.1)	0.081
IL-2	2.2 (1.2-4.2)	0.011	2.7 (1.4-5.4)	0.005
IL-4	2.4 (1.2-4.6)	0.014	2.3 (1.1-4.5)	0.018
IL-8/CXCL8	2.6 (1.4-4.6)	0.002	1.6 (0.9-3.0)	0.115
IL-10	2.2 (1.2-4.1)	0.014	2.3 (1.2-4.6)	0.014
TNF-α	1.6 (0.9-2.8)	0.104	1.5 (0.8-2.6)	0.202

¹When adjusted for age, TNM stage, radical surgery, preoperative- and adjuvant treatment.