Suspicious brush cytology is an indication for liver transplantation evaluation in primary sclerosing cholangitis

Table 1 Histological findings in 30 explanted livers of primary sclerosing cholangitis patients with biliary low-grade dysplasia or high-grade dysplasia/cholangiocarcinoma

	LGD	HGD + CCA2	P value
n	16	14
Early LT1, n	12	11	1.000
Histology intrahepatic
Liver weight, g (IQR)	1380 (1190-1717)	1408 (1262-1487)	0.910
Fibrosis stage 1-4 (IQR)	3.5 (3.0-4.0)	3.0 (2.0-4.0)	0.473
Stage 1-2, n	3	4	0.675
Stage 3-4, n	13	10	0.675
Histology extrahepatic, n
Purulent cholangitis	12	6	0.142
Ulceration	11	6	0.224
Intestinal metaplasia	2	1	0.822
Squamous metaplasia	1	0	0.790

¹In early LTs, suspicion of biliary neoplasia was an important decision criterion for LT;

²CCA four patients; HGD ten patients. Values are median values unless otherwise indicated (IQR). P values: Mann-Whitney U-test for continuous variables, Fisher's exact test for dichotomous variables. CCA: Cholangiocarcinoma; HGD: High-grade dysplasia; IQR: Interquartile range; LGD: Low-grade dysplasia; LT: Liver transplantation.