Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

Table 3 Odds-ratios for immune mediated diseases, in patients with inflammatory bowel disease

Disease	IBD	95%CI	UC	95%CI	CD	95%CI	Both1	95%CI
Primary sclerosing cholangitis	126.7a	47.2-340.3	189.5a	47.0-763.4	68.8a	9.4-502.6	59.4a	8.1-436.2
Pyoderma gangrenosum	47.5a	23.4-96.4	27.3a	12.7-58.7	118.2a	16.4-853.3	36/0a2
Autoimmune hepatitis	7.0a	4.8-10.1	8.6a	5.4-13.6	2.7b	1.2-5.8	12.8a	2.9-56.8
Celiac disease	6.0a	4.7-7.6	4.5a	3.3-6.1	8.8a	5.9-13.0	7.4a	2.4-22.3
Ankylosing spondylitis	5.6a	4.7-6.8	3.9a	3.1-4.9	11.7a	8.1-17.1	4.8a	2.7-8.4
Churg Strauss syndrome	5.5a	2.0-15.3	3.9b	1.2-13.0	-c		-c
Primary biliary cholangitis	4.4a	2.9-6.6	4.2a	2.6-6.7	3.6b	1.3-9.7	13.8b	1.7-111.9
Episcleritis	3.3a	2.2-5.1	2.1b	1.2-3.9	5.5a	2.5-11.7	5.2b	1.4-19.8
Iridocyclitis	2.8a	2.4-3.3	2.4a	2.0-2.9	3.6a	2.7-4.7	3.2a	2.0-5.4
Atrophic gastritis	2.5a	1.7-3.7	2.4a	1.5-3.8	2.9b	1.3-6.2	-c
Psoriasis	2.2a	1.9-2.5	1.7a	1.4-2.1	3.0a	2.3-3.8	3.5a	1.9-6.5
Polyarteritis nodosa	2.2a	1.4-3.4	1.7b	1.0-3.0	3.3b	1.4-7.5	-c
Rheumatoid arthritis	1.8a	1.5-2.0	1.6a	1.3-1.9	2.1a	1.6-2.8	2.5a	1.5-4.2
Type 1 diabetes	1.7a	1.6-1.9	1.7a	1.6-1.8	1.7a	1.4-1.9	2.9a	2.2-3.9
Sarcoidosis	1.7a	1.3-2.2	1.7a	1.2-2.2	-c		3.1b	1.9-4.8
Asthma	1.7a	1.6-1.9	1.6a	1.4-1.8	1.8a	1.6-2.1	1.8a	1.3-2.5
Giant cell arteritis	1.6a	1.3-2.0	1.6a	1.3-2.1	1.6b	1.0-2.4	-c
Psoriatic arthritis	1.5a	1.3-1.8	1.4b	1.1-1.7	1.7a	1.3-2.3	2.4b	1.3-4.6
Grave's disease	1.4a	1.3-1.6	1.4a	1.2-1.6	1.3b	1.1-1.7	1.9b	1.2-2.8
Polymyalgia rheumatica	1.3a	1.2-1.5	1.5a	1.2-1.7	-c		-c

^aP < 0.00125;

^bP = 0.00125-0.05;

^cP > 0.05;

¹Patients registered with both CD and UC;

²No. of cases in IBD cohort/No. of cases in control cohort. CD: Crohn’s disease; UC: Ulcerative colitis; IBD: Inflammatory bowel disease.