Prospective Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Aug 28, 2017; 23(32): 5969-5976
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5969
Table 1 Baseline clinical characteristics of patients after kidney transplantation treated with sofosbuvir and daclatasvir
Patient number123456
Age/gender47/M40/M40/M48/M48/M49/M
Pre-treatment serum HCV viral load (IU/mL)3.2E+68.6E+51.4E+75.14E+52.95E+78.08E+5
HCV genotype1b1b3a1b6a1b
Anti-HCVNegativePositivePositivePositiveNegativePositive
CirrhosisNoNoNoNoNoNo
Number of kidney transplantationsTwoOneOneOneOneOne
Prior antiviral therapyNoNoNoNoNoNo
Baseline serum Cr (μmol/L) (n = 53-115)75.584.2146.6175.612889.3
Baseline eGFR (mL/min)63.6380.0442.8630.9448.2961.85
Baseline Hgb (g/dL)113136121111167137
Baseline ALT (IU/L)686726132644
Baseline AST (IU/L)16114342274254
Baseline γ-GT (IU/L)16262155256054
Baseline TB (μmol/L)3029.29.6818.712.5
Baseline (Hb g/L)11313612194167137
ComplicationHypertensionHypertensionHypertensionHypertensionHypertension/DiabetesHypertension
Antiviral regimenSofosbuvir 400 mg daily + daclatasvir 6 0mg dailySofosbuvir 400 mg daily + daclatasvir 60 mg dailySofosbuvir 400 mg daily + daclatasvir 60 mg daily + ribavirin 0.6 g dailySofosbuvir 400 mg daily + daclatasvir 60 mg dailySofosbuvir 400 mg daily + daclatasvir 60 mg dailySofosbuvir 400 mg daily + daclatasvir 60 mg daily
Treatment duration (wk)121212121212
Baseline immunosuppressive regimenMycophenolatemofetil 500 mg bidMycophenolate mofetil 540 mg bidMycophenolate mofetil 540 mg bidMycophenolate mofetil 750 mg bidCyclosporin A 75 mg bidMycophenolate mofetil 720 mg bid
Tacrolimus (FK506) 0.5 mg bidTacrolimus (FK506)1.5 mg bidTacrolimus (FK506)2 mg bidTacrolimus 2 mg bidMycophenolate mofetil 540 mg bidTacrolimus (FK506) 0.5 mg bid
Methylprednisolone 4 mg qdPrednisone 5 mg qdPrednisone 5mg qdPrednisone 5 mg qdPrednisone 5 mg qdMethylprednisolone 4 mg qd
Baseline anti-hypertension regimenMetoprolol 12.5 mg qdBenazepril 10 mgBenazepril 10 mg bidValsartan 80 mg bidIrbesartan 150 mg bidNone
qd
Valsartan 80 mg qd
Other regimensBenzbromarone tablets 12.5 mg bidRecombinant human erythropoietin injection 10000 U, IH, biw