Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis

Table 1 Impact of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten on liver function in rat liver fibrosis induced by CCl₄ in prevention groups at different time points

Group	ALT (U/L)	AST (U/L)	ALB (g/L)	TBIL (μmol/L)	DBIL (μmol/L)
Pre 1 wk
Control	58.09 ± 6.54	147.23 ± 10.25	28.95 ± 2.14	2.15 ± 0.54	1.12 ± 0.32
CCl4	414.45 ± 29.37	339.12 ± 45.37	27.20 ± 2.35	2.12 ± 0.38	1.70 ± 0.21
Ad-GFP	426.24 ± 30.76	289.37 ± 20.76	27.92 ± 3.12	2.13 ± 0.31	1.56 ± 0.12
Ad-PTEN	404.23 ± 26.78	283.76 ± 23.45a	29.12 ± 4.25	1.98 ± 0.34	1.42 ± 0.31
Ad-G129E	409.98 ± 43.24	289.76 ± 35.43a	28.82 ± 3.23	2.00 ± 0.34	1.50 ± 0.21
PTEN shRNA	2970.11 ± 267.34b	1690.25 ± 200.34b	27.10 ± 3.23	4.03 ± 0.78b	2.67 ± 0.56b
Pre 3 wk
Control	60.71 ± 5.34	150.54 ± 12.34	27.65 ± 3.28	2.34 ± 0.23	1.28 ± 0.77
CCl4	532.21 ± 34.02	804.12 ± 67.34	25.31 ± 4.32	17.31 ± 1.21	7.78 ± 2.01
Ad-GFP	589.34 ± 26.45	787.45 ± 43.21	26.70 ± 3.15	15.04 ± 2.12	7.34 ± 1.29
Ad-PTEN	422.37 ± 34.23a	478.43 ± 50.34a	27.31 ± 2.43	5.78 ± 1.01a	3.24 ± 0.78a
Ad-G129E	506.45 ± 57.32	526.43 ± 32.98a	26.59 ± 1.37	10.54 ± 2.76a	6.21 ± 2.37
PTEN shRNA	3440.32 ± 342.32b	3090.39 ± 228.23b	24.41 ± 2.34b	28.37 ± 4.78b	14.56 ± 2.42b
Pre 5 wk
Control	59.22 ± 7.34	145.38 ± 11.32	28.37 ± 2.56	2.34 ± 0.78	1.43 ± 0.22
CCl4	672.34 ± 17.37	817.56 ± 46.32	26.70 ± 3.02	15.23 ± 2.78	7.65 ± 1.22
Ad-GFP	597.45 ± 33.21	753.24 ± 32.12	26.30 ± 1.76	16.30 ± 3.56	8.72 ± 2.11
Ad-PTEN	456.43 ± 32.12a	566.76 ± 53.21a	28.54 ± 2.12a	9.31 ± 2.12a	4.50 ± 0.89a
Ad-G129E	492.37 ± 40.65a	705.43 ± 63.21a	27.21 ± 1.35	10.56 ± 1.23a	5.61 ± 1.23a
PTEN shRNA	2060.21 ± 325.34b	2490.34 ± 532.12b	24.23 ± 1.23b	17.31 ± 2.67b	9.45 ± 2.12b
Pre 7 wk
Control	60.21 ± 3.19	152.12 ± 15.34	28.34 ± 1.15	2.38 ± 0.59	1.48 ± 0.26
CCl4	605.23 ± 85.37	1110.32 ± 215.32	22.76 ± 3.21	15.26 ± 1.23	8.65 ± 0.32
Ad-GFP	623.45 ± 56.34	1134.23 ± 121.24	23.43 ± 1.21	14.87 ± 1.02	9.34 ± 0.98
Ad-PTEN	456.45 ± 32.12a	183.23 ± 34.23a	26.73 ± 2.23a	4.32 ± 0.97	2.62 ± 0.42
Ad-G129E	545.87 ± 43.21a	694.32 ± 25.34a	25.63 ± 1.23a	4.56 ± 0.32	2.54 ± 0.23
PTEN shRNA	1825.23 ± 28.23b	1878.45 ± 56.87b	21.90 ± 3.23b	17.23 ± 3.56b	9.08 ± 1.32b

Data are presented as mean ± SD for n = 3.

^aP < 0.01 vs CCl₄, Ad-GFP;

^bP < 0.05 vs CCl₄, Ad-GFP, Ad-PTEN. ALB: Albumin; ALT: Alanine transaminase; AST: Aspartate transaminase; DBIL: Direct bilirubin; PTEN: Phosphatase and tension homologue deleted on chromosome ten; TBIL: Total bilirubin.