Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer

Table 6 Correlations between TTK expression and clinicopathological parameters

Parameter	TTK expression		χ2	P-value
	Low expression	High expression
Age (yr)
≤ 65	16	17	0.059	0.808
> 65	18	17
Gender
Female	20	19	0.277	0.598
Male	13	16
CEA
Normal	20	22	3.512	0.061
Elevated	12	4
CA 19-91
Normal	10	16	5.756	0.0161
Elevated	23	10
Tumor size
≤ 3	22	21	0.063	0.801
> 3	12	13
Differentiation1
Lowly-undifferentiated	11	4	4.191	0.0411
Moderately-well	23	30
T stage1
1 + 2	8	25	17.015	< 0.0011
3	26	9
Nodal involvement1
Negative	12	26	11.691	< 0.0011
Positive	22	8
Metastasis1
M0	27	33	5.100	0.0241
M1	7	1
TNM stage 1
I + II	5	23	19.671	< 0.0011
III + IV	29	11

¹Statistically significant. CEA: Carcinoembryonic antigen; TTK: Threonine and tyrosine kinase.