Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma

Table 2 Association between doublecortin and CaM kinase-like-1 expression and clinicopathological factors in resected pancreatic ductal adenocarcinoma n (%)

Characteristic	DCLK-1, n = 136		P value
	Positive, n = 66	Negative, n = 70
Tumor size in cm			0.2962
< 2	11 (16.7)	17 (24.3)
≥ 2	55 (83.3)	53 (75.7)
Histological grade			0.0290
G1	5 (7.6)	15 (21.4)
G2-4	61 (92.4)	55 (78.6)
T category			0.4326
T1/T2	14 (21.2)	19 (27.1)
T3/T4	52 (78.8)	51 (72.9)
N category			1.00
N0	34 (51.5)	37 (52.9)
N1	32 (48.5)	33 (47.1)
Serum CA19-9 level			0.0060
Normal	14 (21.2)	31 (44.3)
Elevated	52 (78.8)	39 (55.7)
Serum SPan-1 level
Normal	23 (34.8)	34 (48.6)	0.1198
Elevated	43 (65.2)	36 (51.4)
Residual tumor			0.2148
R0	38 (57.6)	48 (68.6)
R1/2	28 (42.4)	22 (31.4)
Snail			0.1237
Positive	41 (62.1)	34 (48.6)
Negative	25 (37.9)	36 (51.4)
E-cadherin			0.1151
Positive	31 (47.0)	23 (32.9)
Negative	35 (53.0)	47 (67.1)
N-cadherin			0.5967
Positive	23 (34.8)	28 (40.0)
Negative	43 (65.2)	42 (60.0)
Vimentin			0.5232
Positive	6 (9.1)	4 (5.7)
Negative	60 (90.9)	66 (94.3)
CD24			0.3758
Positive	27 (40.9)	23 (32.9)
Negative	39 (59.1)	47 (67.1)
CD44			1.00
Positive	49 (74.2)	52 (74.3)
Negative	17 (25.8)	18 (25.7)
EpCAM			0.0235
Positive	46 (69.7)	35 (50.0)
Negative	20 (30.3)	35 (50.0)
CD133			0.8301
Positive	12 (18.2)	14 (20.0)
Negative	54 (81.8)	56 (80.0)
CD24+CD44+EpCAM+			0.0139
Positive	18 (27.3)	7 (10.0)
Negative	48 (72.7)	63 (90.0)

DCLK1: Doublecortin and CaM kinase-like-1; EpCAM; Epithelial cell adhesion molecule; PDAC: Pancreatic ductal adenocarcinoma.